Effect of absorbable and nonabsorbable sugars on intestinal calcium absorption in humans

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Gastroenterology; (United States)

OSTI ID:6464053

Griessen, M; Speich, P V; Infante, F; Bartholdi, P; Cochet, B; Donath, A; Courvoisier, B; Bonjour, J P

The effects of glucose, galactose, and lactitol on intestinal calcium absorption and gastric emptying were studied in 9, 8, and 20 healthy subjects, respectively. Calcium absorption was measured by using a double-isotope technique and the kinetic parameters were obtained by a deconvolution method. The gastric emptying rate was determined with /sup 99m/Tc-diethylenetriaminepentaacetic acid and was expressed as the half-time of the emptying curve. Each subject was studied under two conditions: (a) with calcium alone and (b) with calcium plus sugar. Glucose and galactose increased the calcium mean transit time and improved the total fractional calcium absorption by 30% (p less than 0.02). Lactitol decreased the mean rate of absorption (p less than 0.001) and reduced the total fractional calcium absorption by 15% (p less than 0.001). The gastric emptying rate did not appear to influence directly the kinetic parameters of calcium absorption. These results show that both glucose and galactose exert the same stimulatory effect as lactose on calcium absorption in subjects with normal lactase whereas lactitol mimics the effects of lactose in lactase-deficient patients. Thus the absorbability of sugars determines their effect on calcium absorption.

• Research Organization: Univ. of Geneva Hospital (Switzerland)
• OSTI ID: 6464053
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 96:3; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ALDEHYDES
ALKALINE EARTH METALS
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
CALCIUM
CARBOHYDRATES
CARBOXYLIC ACIDS
CHELATING AGENTS
DISACCHARIDES
DRUGS
DTPA
ELEMENTS
GALACTOSE
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LACTOSE
METALS
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
OLIGOSACCHARIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
REACTION KINETICS
SACCHARIDES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
UPTAKE
YEARS LIVING RADIOISOTOPES