Cocarcinogenicity of phenols from Estonian shale tars (oils)

Journal Article · Fri Jun 01 04:00:00 EDT 1979 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.7930177· OSTI ID:5760524

Bogovski, P A; Mirme, H I

Many phenols have carcinogenic activity. The Estonian shale oils contain up to 40 vol % phenols. The promoting activity after initiation of phenols of Estonian shale oils was tested in mice with a single subthreshold dose (0.36 mg) of benzo(a)pyrene. C57B1 and CC57Br mice were used in skin painting experiments. Weak carcinogenic activity was found in the total crude water-soluble phenols recovered from the wastewater of a shale processing plant. In two-stage experiments a clear promoting action of the total crude phenols was established, whereas the fractions A and B (training reagents), obtained by selective crystallization of the total phenols exerted a considerably weaker promoting action. Epo-glue, a commercial epoxy product produced from unfractionated crude phenols, had no promoting activity, which may be due to the processing of the phenols involving polymerization.

• OSTI ID: 5760524
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 30; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
ASIA
BENZOPYRENE
BIOLOGICAL EFFECTS
CARCINOGENESIS
CONDENSED AROMATICS
DOSE-RESPONSE RELATIONSHIPS
EASTERN EUROPE
EUROPE
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
LIQUID WASTES
MAMMALS
MICE
ORGANIC COMPOUNDS
OTHER ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PATHOGENESIS
PHENOLS
RODENTS
SHALE TAR
TAR
USSR
VERTEBRATES
WASTE WATER
WASTES
WATER