Carcinogenicity studies of Estonian oil shale soots

Journal Article · Fri Jun 01 04:00:00 EDT 1979 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.2307/3429120· OSTI ID:5704775

Vosamae, A I

Several series of chronic experiments in white mice and white rats were carried out in order to determine the carcinogenicity of Estonian oil shale soot as well as the soot from oil shale fuel oil. All the investigated samples of soot showed a relatively low (from 14 to 1200 ppM) benzo(a)pyrene content. The benzene extract of oil shale soot, painted on the skin of white mice, proved to be strongly carcinogenic: in most of the animals skin tumors developed. The benzene extract of shale fuel oil exerted a considerably weaker carcinogenic action than the extract of soot of solid shale. The effect of oil shale soots as well as of tars extracted from oil shale soot on the bronchial mucosa and lung respiratory tissue was studied in white rats. Lung tumors were induced in a considerable number of cases in a series of experiments, where the tarry material from solid fuel soot, containing 1070 ppM benzo(a)pyrene, as a suspension in an aqueous solution of Tween 40, was administered by repeated intratracheal instillation. Lung tumor incidence among various control and experimental groups of rats is presented. The peculiarities of oil shale combustion are described.

• OSTI ID: 5704775
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 30; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

04 OIL SHALES AND TAR SANDS
040700 -- Oil Shales & Tar Sands-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
ASIA
BENZOPYRENE
BIOLOGICAL EFFECTS
BITUMINOUS MATERIALS
BODY
CARBONACEOUS MATERIALS
CARCINOGENESIS
CONDENSED AROMATICS
DISEASES
EASTERN EUROPE
ENERGY SOURCES
EUROPE
FOSSIL FUELS
FUEL OILS
FUELS
HYDROCARBONS
LIQUID FUELS
LUNGS
MAMMALS
MATERIALS
MICE
MINERAL OILS
OIL SHALES
OILS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PETROLEUM PRODUCTS
RATS
RESPIRATORY SYSTEM
RODENTS
SHALE OIL
SHALE TAR
SKIN DISEASES
SOOT
TAR
USSR
VERTEBRATES