uv-induced unscheduled DNA synthesis in guinea pig skin melanocytes isolated in culture
Journal Article
·
· J. Invest. Dermatol.; (United States)
Pigmented melanocytes isolated in culture from the epidermis of guinea pig ears were used to study the unscheduled DNA synthesis (UDS) induced by ultraviolet (uv) irradiation at 254 nm. After irradiation, the cells were labeled for 6 h with 3H-thymidine (3HTdR), fixed, dehydrated, and flat embedded in Epon. Radioautographs were made on serial 0.5 to 1 micrometer thick sections of the cultures in order to distinguish silver grains from pigment granules. Cells irradiated with 5, 10, or 50 joules (J) m-2 showed a 3HTdR uptake due to UDS, whereas their proliferative ability, measured by the 3HTdR uptake due to scheduled DNA synthesis, was very low. For the same uv doses, UDS was lower in melanocytes than in guinea pig fibroblasts and keratinocytes.
- Research Organization:
- Institut de Pathologie Cellulaire INSERM, Paris, France
- OSTI ID:
- 5760471
- Journal Information:
- J. Invest. Dermatol.; (United States), Journal Name: J. Invest. Dermatol.; (United States) Vol. 70:1; ISSN JIDEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AZINES
CELL CULTURES
CELL PROLIFERATION
DNA
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MELANIN
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PYRIMIDINES
RADIATIONS
RADIOINDUCTION
RADIONUCLIDE KINETICS
RADIOSENSITIVITY EFFECTS
RIBOSIDES
RODENTS
THYMIDINE
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AZINES
CELL CULTURES
CELL PROLIFERATION
DNA
DNA REPLICATION
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
GUINEA PIGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
LABELLED COMPOUNDS
MAMMALS
MELANIN
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PIGMENTS
PYRIMIDINES
RADIATIONS
RADIOINDUCTION
RADIONUCLIDE KINETICS
RADIOSENSITIVITY EFFECTS
RIBOSIDES
RODENTS
THYMIDINE
TRITIUM COMPOUNDS
ULTRAVIOLET RADIATION
VERTEBRATES