Cadmium nephropathy: monitoring for early evidence of renal dysfunction

Journal Article · Wed Jul 01 04:00:00 EDT 1981 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1981.10667621· OSTI ID:5760231

Murray, T ^[1]; Walker, B R; Spratt, D M; Chappelka, R

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1. Univ. of Pennsylvania, Philadelphia

Prospective studies in humans comparing various tests of cadmium-induced nephropathy have not been reported. Consequently, it is not possible to ascertain which screening methods should be followed in order to detect early nephropathy at a reversible stage. To obtain such data, the authors studied 23 cadmium workers with periodic analyses of blood/urine cadmium levels, hair cadmium content, urinary cytologies, creatinine clearance and urinary levels of lysozyme, ..beta..-2-microglobulins, immunoglobulins, and aminoacids. Blood/urine levels were useful only as indices of acute environmental exposure and not as predictors of total body content or possible nephropathy. Hair content was elevated in most works. Urine cytology was not reliable. Until further data are available, it is suggested that all five measures of renal function be used in screening and follow-up of cadmium workers for preventing nephropathy.

• OSTI ID: 5760231
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 36:4; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CADMIUM
CHEMICAL ANALYSIS
DISEASES
ELEMENTS
HAIR
HAZARDS
HEALTH HAZARDS
INDUSTRY
KIDNEYS
MATERIALS
METAL INDUSTRY
METALS
ORGANS
PERSONNEL
QUALITATIVE CHEMICAL ANALYSIS
SKIN
TOXICITY
URINE
UROGENITAL SYSTEM DISEASES
WASTES