Renal and blood pressure effects from environmental cadmium exposure in Thai children

Journal Article · Thu Jan 15 04:00:00 EST 2015 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2014.10.017· OSTI ID:22447562

Swaddiwudhipong, Witaya ^[1]; Mahasakpan, Pranee ^[1]; Jeekeeree, Wanpen ^[2]; Funkhiew, Thippawan ^[1]; Sanjum, Rungaroon; Apiwatpaiboon, Thitikarn ^[2]; Phopueng, Ittipol ^[1]

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1. Department of Community and Social Medicine, Mae Sot General Hospital, Tak 63110 (Thailand)
2. Department of Medical Technology, Mae Sot General Hospital, Tak 63110 (Thailand)

Very few studies have shown renal and blood pressure effects from environmental cadmium exposure in children. This population study examined associations between urinary cadmium excretion, a good biomarker of long-term cadmium exposure, and renal dysfunctions and blood pressure in environmentally exposed Thai children. Renal functions including urinary excretion of β{sub 2}-microglobulin, calcium (early renal effects), and total protein (late renal effect), and blood pressure were measured in 594 primary school children. Of the children studied, 19.0% had urinary cadmium ≥1 μg/g creatinine. The prevalence of urinary cadmium ≥1 μg/g creatinine was significantly higher in girls and in those consuming rice grown in cadmium-contaminated areas. The geometric mean levels of urinary β{sub 2}-microglobulin, calcium, and total protein significantly increased with increasing tertiles of urinary cadmium. The analysis did not show increased blood pressure with increasing tertiles of urinary cadmium. After adjusting for age, sex, and blood lead levels, the analysis showed significant positive associations between urinary cadmium and urinary β{sub 2}-microglobulin and urinary calcium, but not urinary total protein nor blood pressure. Our findings provide evidence that environmental cadmium exposure can affect renal functions in children. A follow-up study is essential to assess the clinical significance and progress of renal effects in these children. - Highlights: • Few studies show renal effects from environmental cadmium exposure in children. • We report renal and blood pressure effects from cadmium exposure in Thai children. • Urinary β{sub 2}-microglobulin and calcium increased with increasing urinary cadmium. • The study found no association between urinary cadmium levels and blood pressure. • Environmental cadmium exposure can affect renal functions in children.

• OSTI ID: 22447562
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 136; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
AUGMENTATION
BIOLOGICAL MARKERS
BLOOD
BLOOD PRESSURE
CADMIUM
CALCIUM
CHILDREN
CREATININE
EDUCATIONAL FACILITIES
EXCRETION
FUNCTIONS
GEOMETRY
KIDNEYS
LEAD
POPULATIONS
PROTEINS
RICE
SEX
THAILAND