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Inhibition of diffusion chamber (DC) granulopoiesis by anti-CSF serum

Journal Article · · Proc. Soc. Exp. Biol. Med.; (United States)
Diffusion chamber granulopoiesis was studied in irradiated mice injected with anti-colony stimulating factor (CSF)serum. Total cellularity, proliferative and nonproliferative granulocytes were markedly suppressed by 4 days injection of antiserum. Moreover, granulocytic stem cells were markedly decreased. This suggests that CSF is necessary for maintaining the integrity of the granulocytic stem cell and for inducing differentiating granulopoiesis.
Research Organization:
Univ. of Pittsburgh School of Medicine, PA
OSTI ID:
5759367
Journal Information:
Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 158; ISSN PSEBA
Country of Publication:
United States
Language:
English

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