Cadmium: in vivo measurement in smokers and nonsmokers

Journal Article · Fri Jul 20 04:00:00 EDT 1979 · Science; (United States)

DOI:https://doi.org/10.1126/science.377488· OSTI ID:5759075

Ellis, K J ^[1]; Vartsky, D; Zanzi, I; Cohn, S H; Yasumura, S

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1. Brookhaven National Lab., Upton, NY

Absolute amounts of cadmium (in milligrams) in the left kidney and concentrations of cadmium (micrograms per gram) in the liver were measured in vivo in 20 healthy adult male volunteers. Organ cadmium levels of smokers were significantly elevated above those of nonsmokers. No relationship was evident between body stores of cadmium (liver and kidney) and cadmium or ..beta../sub 2/-microglobulin in urine or blood. The average total body burden of cadmium in man at age 50 is estimated to be 19.3 milligrams for nonsmokers and 35.5 milligrams for smokers (38.7 pack-year smoking history). Biological half-time for the whole body was, on average, 15.7 years (10- to 33-year range). Dietary absorption was 2.7 micrograms per day. Cigarette smoking resulted in the absorption of 1.9 micrograms per pack.

• DOE Contract Number: EY-76-C-02-0016
• OSTI ID: 5759075
• Journal Information: Science; (United States), Journal Name: Science; (United States) Vol. 205; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BODY
CADMIUM
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
IN VIVO
KIDNEYS
LIVER
MAMMALS
MAN
MEASURING INSTRUMENTS
METALS
NEUTRON ACTIVATION ANALYZERS
ORGANS
PRIMATES
VERTEBRATES