Manganese binding proteins in human and cow's milk

Journal Article · Fri Mar 01 04:00:00 EST 1985 · Am. J. Clin. Nutr.; (United States)

OSTI ID:5754894

Loennerdal, B; Keen, C L; Hurley, L S

Manganese nutrition in the neonatal period is poorly understood, due in part to a lack of information on the amount of manganese in infant foods and its bioavailability. Since the molecular localization of an element in foods is one determinant of its subsequent bioavailability, a study was made of the binding of manganese in human and cow's milk. An extrinsic label of /sup 54/Mn was shown to equilibrate isotopically with native manganese in milks and formulas. Milk samples were separated into fat, casein and whey by ultracentrifugation. In human milk, the major part (71%) of manganese was found in whey, 11% in casein and 18% in the lipid fraction. In contrast, in cow's milk, 32% of total manganese was in whey, 67% in casein and 1% in lipid. Within the human whey fraction, most of the manganese was bound to lactoferrin, while in cow's whey, manganese was mostly complexed to ligands with molecular weights less than 200. The distribution of manganese in formulas was closer to that of human milk than of cow's milk. The bioavailability of manganese associated with lactoferrin, casein and low molecular weight complexes needs to be assessed.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5754894
• Journal Information: Am. J. Clin. Nutr.; (United States), Journal Name: Am. J. Clin. Nutr.; (United States) Vol. 41:3; ISSN AJCNA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AGE GROUPS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BODY FLUIDS
CATTLE
CHEMICAL BONDS
CHILDREN
COMPLEXES
DAYS LIVING RADIOISOTOPES
DIET
DOMESTIC ANIMALS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FOOD
INFANTS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPE RATIO
ISOTOPES
LIGANDS
MAMMALS
MAN
MANGANESE
MANGANESE 54
MANGANESE ISOTOPES
MATERIALS
METALS
MILK
MOLECULAR STRUCTURE
MOLECULAR WEIGHT
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOISOTOPES
RUMINANTS
TRACER TECHNIQUES
TRANSITION ELEMENTS
VERTEBRATES