Effect of age on manganese uptake and retention from milk and infant formulas in rats

Journal Article · Sat Mar 01 04:00:00 EST 1986 · J. Nutr.; (United States)

OSTI ID:5674384

Keen, C L; Bell, J G; Loennerdal, B

Manganese nutrition of the neonate is poorly understood, due in part to a paucity of information on the amount and availability of manganese in infant foods. We have developed a suckling pup model to assess the uptake of manganese from fluid diets by using extrinsic labeling. Human milk, cow milk and infant formulas were fed by intubation to fasted rat pups and adults. Rats were killed after varying time periods, and tissues were removed and counted. A period of 6 h was found to be adequate to allow for stomach emptying while limiting tissue redistribution; 24 h was found to reflect pup manganese retention. From human milk, manganese retention was highest (greater than or equal to 80%) in pups less than or equal to 15 days of age; in older pups average retention decreased to 40%. Using d 14 pups to assess relative Mn uptake from diets, wholebody Mn uptake was highest from cow milk (approximately 89%); uptake from human and cow milk formula was similar (approximately 80%) whereas it was lower from soy formula (approximately 60%). These findings suggest that bioavailability of Mn from infant diets is very high during the suckling period. Since most formulas contain considerably more manganese than is found in human milk, Mn deficiency may be less of a concern than possible toxicity from formulas.

• Research Organization: Univ. of California, Davis
• OSTI ID: 5674384
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 3; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
AGE DEPENDENCE
ANIMALS
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BODY FLUIDS
CATTLE
DISTRIBUTION
DOMESTIC ANIMALS
ELEMENTS
FOOD
INTESTINAL ABSORPTION
MAMMALS
MANGANESE
MATERIALS
METALS
MILK
NEONATES
PREGNANCY
RATS
RETENTION
RODENTS
RUMINANTS
TISSUE DISTRIBUTION
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES