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Influence of retinol on carcinogen-induced sister chromatid exchangers and chromosome aberrations in V79 cells

Journal Article · · Environ. Mutagen.; (United States)
; ;

The influence of retinol (Rol) on sister chromatid exchangers (SCE) in V79 cells induced by six indirect and two direct carcinogens, and on chromosome aberration (CA) in V79 cells induced by four indirect carcinogens were studied. The indirect carcinogens used were aflatoxin B/sub 1/ (AFB), cyclophosphamide (CPP), benzo(a)anthracene (BA), benzo(a)pyrene (BP), 9,10-dimethyl-1,2-benz(a)anthracene (DMBA), and 3-methylcholanthrene (MCA). The two direct carcinogens were ethyl methane sulfonate (EMS) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Rol effectively inhibited SCE and CA induced by AFB and CPP in a dose-dependent manner, but it had no effect on SCE induced by BA, BP, DMBA, MCA, EMS, and MNNG. To the contrary, Rol had an enhancing effect on CA induced by BP and DMBA. The possibility that Rol exerts its anticarcinogenic effects by inhibiting certain forms of the cytochrome P-450 isoenzymes required for activation of precarcinogens, such as AFB and CPP but not those enzymes required by BA, BP, DMBA, and MCA, is discussed.

Research Organization:
Roswell Park Memorial Institute, Buffalo, NY
OSTI ID:
5748609
Journal Information:
Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 7:2; ISSN ENMUD
Country of Publication:
United States
Language:
English

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Related Subjects

3-METHYLCHOLANTHRENE
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFLATOXIN
ALKYLATING AGENTS
ANIMAL CELLS
ANTIGENS
AROMATICS
BENZANTHRACENE
BENZOPYRENE
BIOLOGICAL EFFECTS
CHROMOSOMAL ABERRATIONS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
DIMETHYLBENZANTHRACENE
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENDOXAN
FIBROBLASTS
HYDROCARBONS
IMMUNOSUPPRESSIVE DRUGS
MATERIALS
MUTATIONS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
TOXIC MATERIALS
TOXINS
VITAMIN A
VITAMINS