Complexes of technetium with pyrophosphate, etidronate, and medronate

Journal Article · Fri Jun 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5741102

Russell, C D; Cash, A G

The reduction of (/sup 99/Tc)pertechnetate was studied as a function of pH in complexing media of pyrophosphate, methylene diphosphonate (MDP), and ethane-1, hydroxy-1, and 1-diphosphonate (HEDP). Test (sampled d-c) and normal-pulse polarography were used to study the reduction of pertechnetate, and normal-pulse polarography (sweeping in the anodic direction) to study the reoxidation of the products. Below pH 6 TcO/sub 4//sup -/ was reduced to Tc(III), which could be reoxidized to Tc(IV). Above pH 10, TcO/sub 4//sup -/ was reduced in two steps to Tc(V) and Tc(IV), each of which could be reoxidized to TcO/sub 4//sup -/. Between pH 6 and 10 the results differed according to the ligand present. In pyrophosphate and MDP, TcO/sub 4//sup -/ was reduced in two steps to Tc(IV) and Tc(III); Tc(III) could be reoxidized in two steps to Tc(IV) and TcO/sub 4//sup -/. In HEDP, on the other hand, TcO/sub 4//sup -/ was reduced in two steps to Tc(V) and Tc(III), and could be reoxidized to Tc(IV) and TcO/sub 4//sup -/. Additional waves were observed; they apparently led to unstable products.

• Research Organization: Veterans Administration Medical Center, Birmingham, AL
• OSTI ID: 5741102
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:6; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
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62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHALCOGENIDES
CHEMICAL PROPERTIES
CHEMICAL REACTIONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGANDS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OXIDATION
OXIDES
OXYGEN COMPOUNDS
PERTECHNETATES
PH VALUE
PHOSPHORUS COMPOUNDS
POLAROGRAPHY
PYROPHOSPHATES
RADIOISOTOPES
REDUCTION
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TECHNETIUM OXIDES
TRANSITION ELEMENT COMPOUNDS
VALENCE
YEARS LIVING RADIOISOTOPES