Complexes of technetium with hydroxycarboxylic acids: gluconic, glucoheptonic, tartaric, and citric

Conference · Sat Nov 01 04:00:00 EST 1980 · J. Nucl. Med.; (United States)

OSTI ID:6887342

Russell, C D; Speiser, A G

Technetium complexes of several hydroxycarboxylic acids are used for medical imaging. To determine the oxidation state of technetium in these agents, we studied the reduction of pertechnetate (Tc-99) in 0.1 M solutions of four hydroxycarboxylic acids, using polarography and amperometric titration with Sn(II). In D-gluconate below pH 6, Tc(III) and Tc(V) complexes were identified with certainty, Tc(IV) questionably; at pH 6 to 10, Tc(IV) and Tc(V) were formed; above pH 10, Tc(III), Tc(IV), and Tc(V). In D-glucoheptonate below pH 6, Tc(III) and Tc(V) were formed, and questionably Tc(IV); at pH 6 to 10, Tc(V); above pH 10, Tc(III), Tc(V), and probably Tc(IV). In L-tartrate below pH 6, Tc(III), Tc(IV), and Tc(V) were formed; above pH 6, Tc(IV) and Tc(V). In citrate below pH 10, Tc(III), Tc(IV), and Tc(V) were formed; above pH 10, Tc(IV) and Tc(V). For all four ligands the initial product of reduction by Sn(II) at pH 3 to 9 was Tc(V). In freshly prepared tin-labeled imaging agents of this class, the oxidation state is probably Tc(V). Lower stable oxidation states exist, attainable by using reducing agents stronger than tin; these may show altered imaging properties.

• Research Organization: Univ. of Alabama, Birmingham
• OSTI ID: 6887342
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 21:11
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AQUEOUS SOLUTIONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACID ESTERS
CARBOXYLIC ACIDS
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
CHEMICAL REACTIONS
CITRIC ACID ESTERS
DIAGNOSTIC USES
DISPERSIONS
DRUGS
ELECTROLYSIS
ESTERS
GLUCOHEPTONATE
GLUCONIC ACID
HOURS LIVING RADIOISOTOPES
HYDROXY ACIDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LYSIS
MATERIALS
MIXTURES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXIDATION
PH VALUE
POLAROGRAPHY
QUANTITATIVE CHEMICAL ANALYSIS
RADIOACTIVE MATERIALS
RADIOISOTOPES
RADIOPHARMACEUTICALS
REDOX POTENTIAL
REDUCTION
SOLUTIONS
SYNTHESIS
TARTARIC ACID ESTERS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TITRATION
USES
YEARS LIVING RADIOISOTOPES