Technetium radiopharmaceuticals: chemical characterization and tissue distribution of Tc-glucoheptonate using Tc-99m and carrier Tc-99

Journal Article · Sat Aug 01 04:00:00 EDT 1981 · J. Nucl. Med.; (United States)

OSTI ID:6255238

de Kieviet, W

The chemical structure of the kidney- and brain-imaging agent Tc-99m glucoheptonate has been established using the Tc-99 isotope. In a comparative study between Tc-99 and Tc-99m glucoheptonathes, chromatographic, electrophoretic, and tissue distribution studies showed identical compounds in 0.9% NaCl. Optimal conditions for the formation of the Tc-99 glucoheptonate complex were investigated by uv and visible spectroscopy. The oxidation state of Tc-99 in the compound is V, measureed by Sn/sup 2 +/ titration. NMR studies demonstrated two five-membered glucoheptonate rings, bidentate bound to Tc by the oxygens of te end carboxyl group and the adjacent hydroxyl group.

• Research Organization: Rotterdamsch Radio-Therapeutisch Inst., Rotterdam, Netherlands
• OSTI ID: 6255238
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:8; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACID ESTERS
CHEMICAL ANALYSIS
CHEMICAL PROPERTIES
DISTRIBUTION
DRUGS
ELECTROPHORESIS
ESTERS
GLUCOHEPTONATE
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAGNETIC RESONANCE
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
RADIOISOTOPES
RADIOPHARMACEUTICALS
RESONANCE
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
YEARS LIVING RADIOISOTOPES