Technetium-99 in generator systems

Journal Article · Sat Mar 31 23:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:5740344

Moore, P W

Technetium-99m solutions always contain Tc-99. The amount varies considerably, depending on production methods and conditions, generator performance, and the time between production or separation and use. There is increasing evidence that labeling and imaging with some radiopharmaceutical kits is adversely affected when the Tc-99 exceeds certain amounts. The sensitivity of particular kits to Tc-99 depends on the ligand, the amount of usable Sn2+, and the ratio of Tc to ligand. Although Tc-99 formed during production is removed in the final steps of generator manufacture, some may appear in early extractions in the solvent extraction process. If elution or extraction efficiencies are high, any Tc-99 is reduced within about two elutions to an insignificant level that is maintained in subsequent elutions. If efficiencies are below about 40%, however, the ratio of Tc-99 to Tc-99m increases with each elution.

• OSTI ID: 5740344
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 4; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
DRUGS
EFFICIENCY
ELEMENTS
HOURS LIVING RADIOISOTOPES
IMPURITIES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE RATIO
ISOTOPES
LABELLED COMPOUNDS
METALS
MOLYBDENUM
NUCLEI
ODD-EVEN NUCLEI
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SOLVENTS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRANSITION ELEMENTS
YEARS LIVING RADIOISOTOPES