Preparation and biological distribution of technetium diphosphonate radiotracers synthesized without stannous ion
Two HEDP complexes of technetium (either Tc-99 or a mixture of Tc-99 and Tc-99m) have been prepared without the use of stannous ion. The first, Tc(NaBH/sub 4/)-HEDP, is synthesized by reduction of TcO/sub 4//sup -/ with NaBH/sub 4/ in the presence of excess HEDP; this is analogous to the preparation of Tc(Sn)-HEDP in commerical kits wherein Sn(II) functions as the reductant. The second, Tc-HEDP, is prepared by substitution of HEDP onto the pre-formed, pre-reduced, technetium center TcBr/sub 6//sup 2 -/. The HEDP-to-Tc ratio in Tc-HEDP was found to be 1.0 by double-labeling procedures (Tc-99 and (/sup 3/H)HEDP), implying that in solution this material is polymeric or at least dimeric. Preparations of Tc(NaBH/sub 4/)-HEDP and Tc-HEDP with Tc-99m are excellent bone-imaging agents in both rats and dogs. Tissue distribution studies in rats show that uptake of Tc(NaBH/sub 4/)-HEDP and Tc-HEDP by the bone is at least equivalent to that achieved by Tc(Sn)-HEDP prepared in commercial kits with Sn(II) as the reductant. Tin is therefore not necessary for the bone-seeking properties of Tc(Sn)-HEDP, and the in vivo distribution of a given HEDP radiotracer seems to depend primarily on the presence of the HEDP ligand and not on the exact nature of the technetium complex itself. Synthesis of technetium radiotracers by a substitution route, rather than by redox, is practicable; this route has the potential of introducing hitherto unattainable flexibility and subtlety into the preparation of technetium radiotracers.
- Research Organization:
- Procter and Gamble Co., Cincinnati, OH
- OSTI ID:
- 6839689
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:9; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHEMICAL PREPARATION
CHEMICAL REACTIONS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
DRUGS
ESTERS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHONIC ACID ESTERS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
REDOX REACTIONS
RODENTS
SCINTISCANNING
SKELETON
SYNTHESIS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TIN COMPOUNDS
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES