The role of testosterone in trichloroethylene penetration in vitro
Journal Article
·
· Environmental Research; (United States)
- Univ. of Medicine and Dentistry of New Jersey, Newark (United States)
Sex differences are known to exist in the metabolism and bioavailability of trichloroethylene (TCE). This study revealed that dermal penetration of ({sup 14}C)TCE in vitro was twofold greater in untreated female than in untreated male Sprague-Dawley rats. Since testosterone has been shown to mediate a wide variety of sex differences, its role in dermal penetration of ({sup 14}C)TCE was investigated. Penetration was measured by using an in vitro evaporation-penetration cell with a 10-hour collection period. Depriving male rats of testosterone (by castration) resulted in increased values for total penetration, area under the curve (AUC), and penetration slopes compared to those found in the female control group. Administration of testosterone to female animals produced values for total penetration, AUC, and penetration slopes significantly lower than those of the female control group.
- OSTI ID:
- 5740108
- Journal Information:
- Environmental Research; (United States), Journal Name: Environmental Research; (United States) Vol. 54:1; ISSN ENVRA; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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Journal Article
·
Sun Jul 01 00:00:00 EDT 1990
· Arteriosclerosis (Dallas); (USA)
·
OSTI ID:6643275
In vivo and in vitro dermal penetration of 2,4,5,2 prime ,4 prime , 5 prime -hexachlorobiphenyl in young and adult rats
Journal Article
·
Sun Oct 01 00:00:00 EDT 1989
· Environmental Research; (USA)
·
OSTI ID:7004372
STUDIES ON RADIATION-INDUCED MAMMARY GLAND NEOPLASIA IN THE RAT. II. THE RESPONSE OF CASTRATE AND INTACT MALE RATS TO 400 r OF TOTAL-BODY IRRADIATION
Journal Article
·
Thu Dec 31 23:00:00 EST 1959
· Radiation Research
·
OSTI ID:4184323
Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANDROGENS
ANDROSTANES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL AVAILABILITY
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CHLORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
HORMONES
HYDROXY COMPOUNDS
IN VITRO
ISOTOPE APPLICATIONS
KETONES
KINETICS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RATS
REACTION KINETICS
RODENTS
SEX DEPENDENCE
SKIN ABSORPTION
STEROID HORMONES
STEROIDS
TESTOSTERONE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ANDROGENS
ANDROSTANES
ANIMALS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL AVAILABILITY
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CHLORINATED ALIPHATIC HYDROCARBONS
HALOGENATED ALIPHATIC HYDROCARBONS
HORMONES
HYDROXY COMPOUNDS
IN VITRO
ISOTOPE APPLICATIONS
KETONES
KINETICS
LABELLED COMPOUNDS
MAMMALS
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RATS
REACTION KINETICS
RODENTS
SEX DEPENDENCE
SKIN ABSORPTION
STEROID HORMONES
STEROIDS
TESTOSTERONE
TRACER TECHNIQUES
UPTAKE
VERTEBRATES