STUDIES ON RADIATION-INDUCED MAMMARY GLAND NEOPLASIA IN THE RAT. II. THE RESPONSE OF CASTRATE AND INTACT MALE RATS TO 400 r OF TOTAL-BODY IRRADIATION
Male Sprngue-Dawler rats, both castrates and intact, had a 50% incidence of breast neoplasms 16 months after exrosure to 400 r of 250-kvp total-body x radiation delivered as a single dose on the fortieth day of age. The dose was measured in air with scattering material in place. Nonexposed intact or castrate Sprague-Dawley male rats of the same age had an incidence of 0 or 6%, respectively. In the time period studied, total-body irradiation induced more breast tumors than were found in nonirradiated rats, and after consideration of the report that nonexposed male rats of this strain allowed to live out their life span have an incidence of neoplasms of the breast that does not exceed 10%, it is suggested that total-body irradiation can be an agent that may hasten onset of neoplasms and also induce a higher incidence of neoplasms of the breast of the male Sprague-Dawley rat, As compared to the reported neoplastic response of the breast of the female Sprague-Dawley rat, the following differences were noted. The latent period between exposure and appearance of breast neoplasms was prolonged in the male; the total incidence of rats with breast neoplasms was lower in the male; and more neoplasms of the breast of the males were classified as fibrosarcoma, From these findings, it was concluded that although both male and female rats of the Spragine-Dawley strain respond to total-body irradiation by the formation of neoplasia of the breast, gonadal hormones can influence the frequency, latent period, and histological appearance of the induced neoplasms. (auth)
- Research Organization:
- Brookhaven National Lab., Upton, N.Y.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-14-006162
- OSTI ID:
- 4184323
- Journal Information:
- Radiation Research, Journal Name: Radiation Research Vol. Vol: 12
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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