STUDIES ON RADIATION-INDUCED MAMMARY GLAND NEOPLASIA IN THE RAT. III. RELATION OF THE NEOPLASTIC RESPONSE TO DOSE OF TOTAL-BODY RADIATION

Journal Article · Tue Mar 01 04:00:00 EST 1960 · Radiation Research

DOI:https://doi.org/10.2307/3570916· OSTI ID:4195697

Bond, V P; Cronkite, E P; Lippincott, S W; Shellabarger, C J

The dose dependency of the breast neoplasia response was studied in female Sprague-Dawley rats exposed to graded doses of acute total-body radiation at 40 days of age. The incidence of neoplasia scored at 10.1 to 11 months was linear on dose between 25 r and 400 r. The extrapolated curve passed through zero incidence at zero dose. Above 400 r, the incidence either remained constant or decreased. Multiple neoplasms in single animals were observed, and histologically the neoplasms were adenocarcinoraas, adenofibromas, fibroadenoraas, and fibrosarcomas. The neoplasms depend on intact ovarian function for maxmal incidence. The dose-effect results are discussed in terms of their adequacy for interpretation in terms of the mechanism of radiation-induced neoplasia. It was emphasized that the data reported on the relation of dose and neoplasia of the rat breast cannot be extrapolated to other types of neoplasia or to other species. It was pointed out that linearity of response for a given tissue might be masked by dependence of the respense on hormones or other factors in addition to radiation. (auth)

• Research Organization: Brookhaven National Lab., Upton, N.Y.
• Sponsoring Organization: USDOE
• NSA Number: NSA-14-009354
• OSTI ID: 4195697
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 12
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ADENOCARCINOMAS
ADENOFIBROMAS
AGE
BIOLOGY AND MEDICINE
BODY
CANCER
CARCINOGENESIS
DIAGRAMS
FIBROADENOMAS
GLANDS
GONADS
HORMONES
IRRADIATION
MAMMARY GLANDS
MATHEMATICS
MICROSCOPY
OVARIES
PHYSIOLOGY
QUANTITY RATIO
RADIATION DOSES
RADIATION EFFECTS
RATS
SEX
TISSUES
TUMORS