Question of bone marrow stromal fibroblast traffic
Journal Article
·
· Ann. N.Y. Acad. Sci.; (United States)
Bone marrow stromal fibroblasts (CFU-F) normally do not exchange bone marrow sites in vivo. Restitution of the CFU-F after radiation damage is primarily recovery by the local fibroblasts from potentially lethal damage. Migration of stromal fibroblasts from shielded sites to an irradiated site makes a minimal contribution, if any, to CFU-F recovery. Determination of the relative contribution of donor stromal cells in bone marrow transplants by karyotyping the proliferating bone marrow stromal cells in vitro may not reflect the relative distribution of fibroblasts in the marrow. If there is residual damage to the host stromal fibroblasts from treatment before transplantation, these cells may not be able to proliferate in vitro. Therefore, an occasional transplanted fibroblast may contribute most of the metaphase figures scored for karyotype.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 5737701
- Journal Information:
- Ann. N.Y. Acad. Sci.; (United States), Journal Name: Ann. N.Y. Acad. Sci.; (United States); ISSN ANYAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BONE MARROW
BONE MARROW CELLS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
FIBROBLASTS
HEMATOPOIETIC SYSTEM
MAMMALS
MICE
MOSAICISM
ORGANS
PARABIOSIS
RADIATION EFFECTS
RECOVERY
RODENTS
SOMATIC CELLS
SPLEEN
TISSUES
TRANSPLANTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BONE MARROW
BONE MARROW CELLS
CELL PROLIFERATION
CONNECTIVE TISSUE CELLS
FIBROBLASTS
HEMATOPOIETIC SYSTEM
MAMMALS
MICE
MOSAICISM
ORGANS
PARABIOSIS
RADIATION EFFECTS
RECOVERY
RODENTS
SOMATIC CELLS
SPLEEN
TISSUES
TRANSPLANTS
VERTEBRATES