Mapping of functional activity in brain with /sup 18/F-fluoro-deoxyglucose

Journal Article · Thu Jan 01 04:00:00 EST 1981 · Semin. Nucl. Med.; (United States)

DOI:https://doi.org/10.1016/S0001-2998(81)80050-5· OSTI ID:5736228

Alavi, A; Reivich, M; Greenberg, J; Hand, P; Rosenquist, A; Rintelmann, W; Christman, D; Fowler, J; Goldman, A; MacGregor, R; Wolf, A

The efficacy of using the /sup 18/F-fluoro-deoxyglucose (/sup 18/F-DG) for measuring regional cerebral glucose utilization in man during functional activation is demonstrated. Normal male volunteers subjected to sensory stimuli (visual, auditory, tactile) exhibited focal increases in glucose metabolism in response to the stimulus. Unilateral visual hemifield stimulation caused the contralateral striate cortex to become more active metabolically than the striate cortex ipsilateral to the stimulated hemifield. Similarly, stroking of the fingers and hand of one arm with a brush produced an increase in metabolism in the contralateral postcentral gyrus compared to the homologous ipsilateral region. The auditory stimulus, which consisted of monaural listening to either a meaningful or nonmeaningful story, caused an increase in glucose metabolism in the right temporal cortex independent of which ear was stimulated. These results demonstrate that the /sup 18/F-DG technique is capable of providing functional maps in vivo in the human brain.

• OSTI ID: 5736228
• Journal Information: Semin. Nucl. Med.; (United States), Journal Name: Semin. Nucl. Med.; (United States) Vol. 11:1; ISSN SMNMA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DYNAMIC FUNCTION STUDIES
FLUORINE 18
FLUORINE ISOTOPES
GLUCOSE
HEXOSES
HOURS LIVING RADIOISOTOPES
IN VIVO
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METABOLISM
METABOLITES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHYSIOLOGY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SACCHARIDES
SCINTISCANNING
STIMULATION
STIMULI