Demonstration of prosthetic activation of central auditory pathways using ( sup 14 C)-2-deoxyglucose

Journal Article · Thu Feb 01 04:00:00 EST 1990 · Laryngoscope; (USA)

OSTI ID:7025914

Evans, D A; Niparko, J K; Altschuler, R A; Frey, K A; Miller, J M ^[1]

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1. Univ. of Michigan Medical Center, Ann Arbor (USA)

The cochlear prosthesis is not applicable to patients who lack an implantable cochlea or an intact vestibulocochlear nerve. Direct electrical stimulation of the cochlear nucleus (CN) of the brain stem might provide a method for auditory rehabilitation of these patients. A penetrating CN electrode has been developed and tissue tolerance to this device demonstrated. This study was undertaken to evaluate metabolic activation of central nervous system (CNS) auditory tracts produced by such implants. Regional cerebral glucose use resulting from CN stimulation was estimated in a series of chronically implanted guinea pigs with the use of ({sup 14}C)-2-deoxyglucose (2-DG). Enhanced 2-DG uptake was observed in structures of the auditory tract. The activation of central auditory structures achieved with CN stimulation was similar to that produced by acoustic stimulation and by electrical stimulation of the modiolar portion of the auditory nerve in control groups. An interesting banding pattern was observed in the inferior colliculus following CN stimulation, as previously described with acoustic stimulation. This study demonstrates that functional metabolic activation of central auditory pathways can be achieved with a penetrating CNS auditory prosthesis.

• OSTI ID: 7025914
• Journal Information: Laryngoscope; (USA), Journal Name: Laryngoscope; (USA) Vol. 100; ISSN 0023-852X; ISSN LARYA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
AUDITORY ORGANS
BIOLOGICAL PATHWAYS
BODY
CARBOHYDRATES
CARBON 14 COMPOUNDS
CENTRAL NERVOUS SYSTEM
DISEASES
ELECTRIC SHOCK
ELECTRODES
GLUCOSE
GUINEA PIGS
HEXOSES
IMPLANTS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEDICAL SUPPLIES
METABOLIC ACTIVATION
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATIENTS
PROSTHESES
RODENTS
SACCHARIDES
SENSE ORGANS
SENSE ORGANS DISEASES
TRACER TECHNIQUES
VERTEBRATES