Mapping of functional activity in brain with /sup 18/F-fluoro-deoxyglucose

Conference · Thu Jan 01 04:00:00 EST 1981

OSTI ID:5896339

Alavi, A; Reivich, M; Greenberg, J; Wolf, A

A model has been designed based on the assumptions of a steady state for glucose consumption, a first-order equilibration of the free /sup 14/C-DG pool in the tissue with the plasma level, and relative rates of phosphorylation of /sup 14/C-DG and glucose determined by their kinetic constants for hexokinase reaction. Using an operational equation based on this model, the metabolic rates of glucose are calculated in various regions of brain (utilizing brain slices and autoradiography). /sup 14/C is a beta emitter and therefore not suitable for noninvasive imaging in man. With the synthesis of /sup 18/F-2-deoxy-2-fluoro-D-glucose (/sup 18/F-DG) all of the requirements for a suitable radiopharmaceutical for the determination of local cerebral metabolism have been met. This agent behaves very similarly to /sup 14/C-DG and therefore, using the above described model and emission tomography, it has become possible to measure regional cerebral metabolism for the first time in man.

• Research Organization: Brookhaven National Lab., Upton, NY (USA); Pennsylvania Univ., Philadelphia (USA). School of Medicine
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 5896339
• Report Number(s): BNL-30224; CONF-810996-1; ON: DE82002856
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBRUM
DIAGNOSTIC TECHNIQUES
FLUORINE 18
FLUORINE COMPOUNDS
FLUORINE ISOTOPES
FUNCTIONS
GLUCOSE
HALOGEN COMPOUNDS
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VARIATIONS