Induction of indigenous immunoglobulin-containing cells by. gamma. -irradiation and lymphoid cell transfer in mice
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:5731676
Mice irradiate with ..gamma..-ray develop large numbers of Ig-containing cells of various isotypes in all the lymphoid tissues examined except the thymus. The maximal dose of irradiation is approximately 500 R/mouse. These indigenous Ig-containing cells start to appear at day 3 post-irradiation, peak at day 6, and subside thereafter. The expression of the indigenous Ig-containing cells can be enhanced in the spleen of recipient mice by passive transfer of various lymphoid cells, except thymocytes. Lymphoid cells from histocompatible donors are more effective enhancers than those from nonhistocompatible donors. Cells involved in the enhancement are primarily T cells. In contrast, when T cells are eliminated from the lymphoid cell inocula, the indigenous Ig-containing cells are reduced to a level lower than that in the irradiated controls. This suppression appears to be mediated by macrophages, since recovery was found when macrophages were removed from these T cell-depleted inocula.
- Research Organization:
- Walter Reed Army Institute of Research, Washington
- OSTI ID:
- 5731676
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 127:5; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Influence of age on the proliferation and peripheralization of thymic T cells
Homing of bone marrow lymphoid cells
Mechanism of stimulation of antibody-forming ability of bone marrow cells of mice immunized with staphylococci
Journal Article
·
Thu Dec 31 23:00:00 EST 1987
· Arch. Pathol.; (United States)
·
OSTI ID:5407235
Homing of bone marrow lymphoid cells
Journal Article
·
Mon May 01 00:00:00 EDT 1978
· Transplantation; (United States)
·
OSTI ID:7286952
Mechanism of stimulation of antibody-forming ability of bone marrow cells of mice immunized with staphylococci
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· Bull. Exp. Biol. Med. (Engl. Transl.); (United States)
·
OSTI ID:6550060
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GLOBULINS
IMMUNOGLOBULINS
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MACROPHAGES
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SPLEEN
TRANSPLANTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GLOBULINS
IMMUNOGLOBULINS
INHIBITION
IONIZING RADIATIONS
IRRADIATION
LEUKOCYTES
LYMPH NODES
LYMPHATIC SYSTEM
LYMPHOCYTES
MACROPHAGES
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
ORGANS
PHAGOCYTES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
SPLEEN
TRANSPLANTS
VERTEBRATES