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Increased salivary gland density on contrast-enhanced CT after head and neck radiation

Journal Article · · AJR, Am. J. Roentgenol.; (United States)
; ; ; ;
In an attempt to determine whether radiation therapy leads to an increased density of salivary glands on subsequent contrast-enhanced CT, 109 CT scans from 78 patients with head and neck tumors were reviewed. The density of parotid and submandibular glands was subjectively evaluated (compared with adjacent muscle) and correlated with treatment including surgery, chemotherapy, and radiation. Density of the parotid and/or submandibular glands was found to be significantly associated with previous irradiation on contrast-enhanced scans (p less than .05). One or both glands were denser than normal in seven (44%) of 16 patients who received only radiation therapy and in eight (38%) of 21 who received chemotherapy and radiation therapy, compared with only two (10%) of 20 patients who received chemotherapy alone and two (4%) of 52 patients who received neither. The type or amount of irradiation, type of chemotherapy, or timing of the CT scan after the initiation of treatment was not found to be significant. We conclude that the density of the parotid and/or submandibular glands on contrast-enhanced CT is frequently increased after radiation therapy for tumors of the head and neck.
Research Organization:
Univ. of Washington, Seattle
OSTI ID:
5723151
Journal Information:
AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 149:6; ISSN AAJRD
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BODY
BODY AREAS
CHEMOTHERAPY
COMPUTERIZED TOMOGRAPHY
CONTRAST MEDIA
DENSITY
DIAGNOSTIC TECHNIQUES
DISEASES
GLANDS
HEAD
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PHYSICAL PROPERTIES
RADIOLOGY
RADIOTHERAPY
SALIVARY GLANDS
SIDE EFFECTS
THERAPY
TOMOGRAPHY