Oral complications of cancer therapies. Pretherapy interventions to modify salivary dysfunction

Journal Article · Mon Jan 01 04:00:00 EST 1990 · NCI Monographs (National Cancer Institute); (USA)

OSTI ID:6748865

Wolff, A; Atkinson, J C; Macynski, A A; Fox, P C ^[1]

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1. National Institute of Dental Research, Bethesda, MD (USA)

Salivary gland dysfunction is a common side effect of cancer therapies. Salivary secretions are reduced rapidly after starting head and neck radiotherapy. Salivary gland dysfunction has also been linked to bone marrow transplantation and to cytotoxic chemotherapy. Salivary gland stimulation during radiation has been suggested as a means of reducing radiation damage. Results of an ongoing study investigating the effects of pilocarpine on radiation-induced salivary gland dysfunction suggest that parotid function was preserved, but not submandibular/sublingual function. Also, patients receiving pilocarpine had less frequent oral complaints. Further research is necessary to develop means of preventing or alleviating the salivary side effects of cancer therapies. 37 references.

• OSTI ID: 6748865
• Journal Information: NCI Monographs (National Cancer Institute); (USA), Journal Name: NCI Monographs (National Cancer Institute); (USA) Vol. 9; ISSN 0893-2751; ISSN NCIME
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DISEASES
DOCUMENT TYPES
DRUGS
GLANDS
HEAD
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOPROTECTIVE SUBSTANCES
RADIOTHERAPY
REVIEWS
SALIVARY GLANDS
SIDE EFFECTS
THERAPY