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Function of the parotid gland following radiation therapy for head and neck cancer

Conference · · Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6528062
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The parotid gland was selected for study of its salivary output before and after radiation therapy for head and neck cancer. Before radiation therapy, a sialogram of the parotid gland was performed with the patient's head positioned for radiation therapy; a lateral radiographic view of the parotid gland was used to compare with the radiation treatment portal to determine the portion of the parotid gland to be irradiated. Samples of stimulated saliva were collected from the parotid gland before and at 1 and 6 months post-radiation. Eighteen patients with head and neck cancer who received radiation therapy were studied. The data showed that in the irradiation of nasopharyngeal, advanced oropharyngeal and Waldeyer's ring lesions, 100% of the parotid gland was irradiated; for the early oropharyngeal and hypopharyngeal lesions, from 30 to 90% of the parotid gland was irradiated and for the supraglottic and oral cavity lesions, 25 to 30% of the parotid gland was irradiated. When 100% of the parotid gland was irradiated, no saliva was produced at 1 month post-radiation; this remained the same when re-tested at 4 to 8 months, however, when any portion of the parotid gland was not irradiated, there was residual salivary function.
Research Organization:
Univ. of Pittsburgh, PA
OSTI ID:
6528062
Conference Information:
Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 7:2
Country of Publication:
United States
Language:
English

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Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
551000 -- Physiological Systems
560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
BODY FLUIDS
DATA
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
GAMMA RADIATION
GLANDS
HEAD
INFORMATION
IONIZING RADIATIONS
IRRADIATION
MATERIALS
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RADIOTHERAPY
SALIVA
SALIVARY GLANDS
SECRETION
SIDE EFFECTS
THERAPY