Parotid Gland Stem Cell Sparing Radiation Therapy for Patients With Head and Neck Cancer: A Double-Blind Randomized Controlled Trial

Journal Article · Tue Feb 15 04:00:00 EST 2022 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2021.09.023· OSTI ID:23198700

Rijn–Dekker, Maria I. van; Stokman, Monique A. ^[1]; Kierkels, Roel G.J. ^[2]; Schaaf, Arjen van der ^[1]; others, and

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1. Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen (Netherlands)
2. Department of Radiation Oncology, Radiotherapiegroep, Deventer (Netherlands)

Radiation therapy for head and neck cancer frequently leads to salivary gland damage and subsequent xerostomia. The radiation response of the parotid glands of rats, mice, and patients critically depends on dose to parotid gland stem cells, mainly located in the gland's main ducts (stem cell rich [SCR] region). Therefore, this double-blind randomized controlled trial aimed to test the hypothesis that parotid gland stem cell sparing radiation therapy preserves parotid gland function better than currently used whole parotid gland sparing radiation therapy.

• OSTI ID: 23198700
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 2 Vol. 112; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEAD
MICE
NECK
NEOPLASMS
PATIENTS
RADIATION DOSES
RADIOTHERAPY
RATS
SALIVARY GLANDS
STEM CELLS