Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element
Journal Article
·
· J. Exp. Med.; (United States)
The adoptive transfer of clinical and histopathologic signs of experimental allergic encephalomyelitis (EAE) requires MHC compatibility between cell donor and cell recipient. The results of adoptive transfer studies using F1 to parent bone marrow chimeras as recipients of parental-derived BP-sensitive spleen cells indicate that this restriction is not expressed at the level of the endothelial cell but is confined to the cells of bone marrow derivation. Furthermore, these results indicate that the development of EAE is not dependent on the activity of MHC-restricted cytotoxic cells.
- Research Organization:
- Veterans Administration Medical Center, Portland, OR
- OSTI ID:
- 5719858
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 166:6; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
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· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
DISEASES
ENCEPHALITIS
ENDOTHELIUM
IMMUNE REACTIONS
IMMUNITY
INFECTIOUS DISEASES
MAMMALS
MOSAICISM
NERVOUS SYSTEM DISEASES
RADIATION CHIMERAS
RATS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TISSUES
VERTEBRATES
VIRAL DISEASES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW CELLS
CHIMERAS
CONNECTIVE TISSUE CELLS
DISEASES
ENCEPHALITIS
ENDOTHELIUM
IMMUNE REACTIONS
IMMUNITY
INFECTIOUS DISEASES
MAMMALS
MOSAICISM
NERVOUS SYSTEM DISEASES
RADIATION CHIMERAS
RATS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TISSUES
VERTEBRATES
VIRAL DISEASES