Prevention of graft-versus-host disease by treatment of bone marrow with gliotoxin in fully allogeneic chimeras and their cytotoxic T cell repertoire
Journal Article
·
· Transplantation; (United States)
Gliotoxin, a secondary fungal metabolite, at nanomolar concentrations, irreversibly inhibits murine T cell proliferation to mitogen. Treatment of allogeneic spleen cells with gliotoxin allows their transfer into sublethally irradiated recipients without inducing a GVH reaction. Gliotoxin treatment of bone marrow allows the establishment of fully allogenic bone marrow chimeras free of GVH disease. The cytotoxic T cell repertoire against influenza virus in these animals is restricted to both host- and donor-type MHC. However, their immune competence is severely compromised by their lack of host MHC-type stimulator cells.
- Research Organization:
- Australian National Univ., Canberra
- OSTI ID:
- 7184443
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 46:1; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Selective resistance of bone marrow-derived hemopoietic progenitor cells to gliotoxin
Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD
Antibody responses in allogeneic radiation chimeras
Journal Article
·
Mon Jun 01 00:00:00 EDT 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5347710
Effects of T cell depletion in radiation bone marrow chimeras. I. Evidence for a donor cell population which increases allogeneic chimerism but which lacks the potential to produce GVHD
Journal Article
·
Sat Oct 01 00:00:00 EDT 1988
· J. Immunol.; (United States)
·
OSTI ID:6557328
Antibody responses in allogeneic radiation chimeras
Thesis/Dissertation
·
Thu Dec 31 23:00:00 EST 1981
·
OSTI ID:6047971
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CELL PROLIFERATION
CHIMERAS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNITY
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MITOGENS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TISSUES
TOXIC MATERIALS
TOXINS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
ANTIGENS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CELL PROLIFERATION
CHIMERAS
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
IMMUNITY
INHIBITION
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MITOGENS
MOSAICISM
ORGANS
RADIATION CHIMERAS
RODENTS
SOMATIC CELLS
SPLEEN CELLS
TISSUES
TOXIC MATERIALS
TOXINS
VERTEBRATES