Cardioplegia does not prevent reperfusion injury induced by intracoronary platelet deposition

Journal Article · Thu Sep 01 04:00:00 EDT 1983 · Circulation; (United States)

OSTI ID:5715140

Rosenbaum, D; Levitsky, S; Silverman, N; Kohler, J; Lipowski, J; LeBreton, G; Feinberg, H

We have shown that after global myocardial ischemia, reperfusion injury may be related to platelet deposition in the coronary microcirculation. The purpose of this study was to determine whether multidose hypothermic potassium cardioplegia suppresses platelet deposition during postischemic reperfusion. Platelets labeled with /sup 111/In and erythrocytes labeled with /sup 51/Cr were injected into dogs subjected to either 120 min of continuous cardiopulmonary bypass (control, n . 4), 60 min of global normothermic myocardial ischemia followed by 50 min of reperfusion (n . 6), or global ischemia with cardioplegia (n . 5). Intracoronary platelet deposition was determined by comparing the double-labeled isotope activity of myocardial biopsy specimens to peripheral blood. Reperfusion after global myocardial ischemia resulted in substantial deposition of platelets within the coronary vasculature in both the cardioplegia-treated (215 +/- 40 platelets/mg) and untreated (269 +/- 95 platelets/mg) groups. These increases were significantly greater than those measured during continuous bypass (48 +/- 2 platelets/mg; p less than .01). Cardioplegia, despite apparent washout of the microcirculation, does not alter platelet deposition. Thus other platelet-stabilizing measures must be used to prevent platelet deposition-induced reperfusion injury after surgical global ischemia.

• Research Organization: Department of Surgery, University of Illinois Medical Center, Chicago
• OSTI ID: 5715140
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 68:3; ISSN CIRCA
• Country of Publication: United States
• Language: English

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550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL MATERIALS
BIOPSY
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHROMIUM 51
CHROMIUM ISOTOPES
CORONARIES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ERYTHROCYTES
EVEN-ODD NUCLEI
HEART
HEART FAILURE
INDIUM 111
INDIUM ISOTOPES
INJURIES
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PERFUSED ORGANS
RADIOISOTOPES
SYMPTOMS
TRACER TECHNIQUES
VASCULAR DISEASES