Metabolic tissue characterization of reperfused canine myocardium by C-11 palmitic acid
While oxidation of fatty acid declines or even ceases during ischemia, the recovery of myocardial fatty acid metabolism after transient ischemia has remained largely unexplored. Using C-11 palmitic acid as a tracer of myocardial fatty acid metabolism, we evaluated in open chest dogs the myocardial retention and subsequent tissue clearance of intracoronary injected C-11 palmitic acid at control and up to 3 hours after a 20 min occlusion of the LAD. In animals with permanent occlusion, the relative size and halftime of the early clearance curve component, representing oxidation of C-11 palmitic acid, differed markedly from control and did not change with ongoing ischemia. In animals with a 20 min coronary occlusion, the relative size of the early C-11 clearance phase was still significantly depressed at 20 and 90 min of reperfusion but had returned to control at 180 min. The tissue C-11 clearance halftimes remained significantly prolonged throughout the entire reperfusion period. Regional function in the reperfused segments monitored with ultrasonic crystals recovered only slowly and was still less than control after 3 hrs of reperfusion. These data indicate that myocardial fatty acid metabolism after transient ishemia recovers slowly. C-11 palmitic acid in conjunction with Positron-CT may thus be useful for studying regional fatty acid metabolism noninvasively following an ischemic injury and may be helpful in identifying reversible tissue injury.
- Research Organization:
- California Univ., Los Angeles (USA)
- DOE Contract Number:
- AC03-76SF00012
- OSTI ID:
- 5349233
- Report Number(s):
- DOE/SF/00012-T21; ON: DE84005633
- Country of Publication:
- United States
- Language:
- English
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550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
ATP
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD CHEMISTRY
BLOOD VESSELS
BODY
CARBON 11
CARBON ISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
CORONARIES
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FUNCTIONS
HEART
ISCHEMIA
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAMMALS
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOCARBOXYLIC ACIDS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RETENTION FUNCTIONS
TOMOGRAPHY
TRACER TECHNIQUES
VASCULAR DISEASES
VERTEBRATES