Effect of acute anemia on endurance capacity, glucose and lactate kinetics, and the relative distribution of blood flow in rodents

Thesis/Dissertation · Thu Jan 01 04:00:00 EST 1987

OSTI ID:5714744

Gregg, S G

The mechanisms investigated include lactate and glucose kinetics and alterations in the relative distribution of blood flow during submaximal exercise. Acute plasma transfusions were performed to lower the oxygen carrying capacity of the blood. Vo{sub 2max} decreased 18% in both sedentary and endurance trained animals. The sedentary anemic animals suffered a 78% decrease in distance when run to exhaustion whereas the trained anemic animals suffered only a 39% decrease in endurance distance, compared to the respective controls. Continuous infusions of (6-{sup 3}H)glucose and (U-{sup 14}C)lactate were performed. At rest there were no differences in the glucose of lactate turnover rates between anemic and control animals. There was an increase in the rates of glucose turnover in anemic animals compared to control animals, as well as elevated lactate turnover rates during exercise compared to control animals. Acute anemia resulted in an increase in sympathetic stimulation during exercise. Furthermore, epinephrine levels were significantly correlated to rate of lactate turnover.

• Research Organization: California Univ., Berkeley, CA (USA)
• OSTI ID: 5714744
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ADRENALINE
ALDEHYDES
ANEMIAS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BLOOD FLOW
CARBOHYDRATES
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
DISEASES
DRUGS
EXERCISE
GLUCOSE
HEMIC DISEASES
HEXOSES
HYDROGEN COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LACTATES
MAMMALS
METABOLISM
MONOSACCHARIDES
NEUROREGULATORS
ORGANIC COMPOUNDS
PATHOGENESIS
RATS
RODENTS
SACCHARIDES
SYMPATHOMIMETICS
SYMPTOMS
THERAPY
TRACER TECHNIQUES
TRANSFUSIONS
TRITIUM COMPOUNDS
VERTEBRATES