Technetium-99m DADS complexes as renal function and imaging agents. II. Biological comparison with iodine-131 hippuran
To find a /sub 99m/Tc agent with a high renal extraction efficiency similar to (/sup 131/)hippuran, 21 analogs of DADS were labeled and evaluated. Preliminary screening by serial gamma camera imaging in rabbits showed that most analogs had a higher liver uptake and/or slower renal clearance, than hippuran. Three agents (P-DADS, AP-DADS, and CAP-DADS), exhibiting a relatively rapid blood clearance and lower liver uptake in the rabbit, were studied in greater detail in comparison with hippuran and CO/sub 2/-DADS-A, the best analog to date. In the rat, the plasma clearance of the four DADS analogs was slower that that of hippuran. In the dog, there was marked hepatic retention of the four DADS compounds. In volunteers, serial posterior images obtained with these (/sup 99m/Tc)DADS complexes showed significant hepatic as well as renal activity. The 1-hr plasma clearance and urinary excretion were much lower than with simultaneously injected hippuran. Although these /sup 99m/Tc agents are satisfactory for imaging the kidneys, they closely mimic the biodistribution of hippuran only in the rabbit, and not in the rate, dog, or man.
- Research Organization:
- State Univ. of New York, Syracuse
- OSTI ID:
- 5709728
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:4; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
BODY
CHELATING AGENTS
CHEMICAL PROPERTIES
CLEARANCE
COMPARATIVE EVALUATIONS
COMPLEXES
CONTRAST MEDIA
COUNTING TECHNIQUES
DATA
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
DOGS
DRUGS
EXCRETION
EXPERIMENTAL DATA
GLANDS
HIPPURAN
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
IODINE 131
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
MAMMALS
MAN
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RENAL CLEARANCE
RETENTION
RODENTS
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
VERTEBRATES
YEARS LIVING RADIOISOTOPES