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Effects of proximal gastric vagotomy and antrectomy on parietal cell function in humans

Journal Article · · Gastroenterology; (United States)
OSTI ID:5708216
; ; ; ;
Both proximal gastric vagotomy and antrectomy reduce maximal gastric acid secretion in vivo by about 60%. The combination of vagotomy and antrectomy reduces the maximal acid secretion by about 80%. This additive effect indicates that these surgical procedures differ in their mode of action. The function of isolated human oxyntic glands was studied before and after vagotomy and antrectomy, respectively, using radioactively labeled aminopyrine as a marker of parietal cell response. The basal accumulation increased after vagotomy, suggesting a vagally controlled inhibitory component. The carbachol response disappeared and the maximal response induced by histamine or dibutyryl-cyclic adenosine monophosphate was reduced by 60% (p less than 0.01) after vagotomy. This reduction could not be overcome by increasing the dose of dibutyryl-cyclic adenosine monophosphate. This indicates an intracellular effect of vagotomy peripheral to dibutyryl-cyclic adenosine monophosphate point of action. Antrectomy did not induce any statistically significant change at the glandular level, indicating that the reduced gastric acid secretion in vivo may be caused by a reduction in the number of oxyntic glands due to a removal of a trophic effect of antral gastrin.
Research Organization:
Univ. of Goeteborg, Sweden
OSTI ID:
5708216
Journal Information:
Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 87:6; ISSN GASTA
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMP
ANIMAL CELLS
ANTIPYRETICS
AUTONOMIC NERVOUS SYSTEM
BIOLOGICAL FUNCTIONS
BIOLOGICAL MARKERS
BIOLOGICAL MATERIALS
BODY
BODY FLUIDS
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DIGESTIVE SYSTEM DISEASES
DISEASES
DRUGS
FUNCTIONS
GASTRIC ACID
GLANDS
INHIBITION
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
MATERIALS
MEDICINE
NERVES
NERVOUS SYSTEM
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PHYSIOLOGY
SURGERY
THERAPY
TRACER TECHNIQUES
ULCERS
VAGUS