Radiation-induced alterations of fracture healing biomechanics
The effects of irradiation on the normal temporal progression of the physical properties of healing fractures were studied in a rat model. Fractures were surgically produced in the femur, stabilized with an intramedullary pin, and irradiated. One group of rats was exposed to 2,500 rads in divided doses over 2 weeks, beginning 3 days after fracture, and compared to a control group with fractures which were not irradiated. Animals were sacrificed at periodic intervals and the bones were tested to failure in torsion. The torque, stiffness, and energy increased and the angle decreased for the nonirradiated specimens in the expected fashion. This progression was deleteriously altered in the irradiated femurs.
- Research Organization:
- Yale Univ. School of Medicine, New Haven, CT
- OSTI ID:
- 5707178
- Journal Information:
- J. Orth. Res.; (United States), Vol. 2:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE FRACTURES
BIOLOGICAL RADIATION EFFECTS
HEALING
FEMUR
FRACTIONATED IRRADIATION
BIOLOGICAL MODELS
MECHANICAL PROPERTIES
RADIATION DOSES
RADIATION INJURIES
RATS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
DOSES
INJURIES
IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
RECOVERY
RODENTS
SKELETON
VERTEBRATES
560152* - Radiation Effects on Animals- Animals