A CONTRIBUTION TO THE PROBLEM OF NORMALIZING THE HEALING OF FRACTURES IN THE CASE OF RADIATION DISEASE (AN EXPERIMENTAL INVESTIGATION)

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Med. Zh. Uzbekistana

OSTI ID:4656598

Golub, F M; Britun, A I

The healing of bone-fractures was studied in 120 rabbits exposed to overall irradiation in a single dose of 400--600 r and in 20 controls. The second metatarsal bone was cut through with scissors 1 day, 1, 3, 4, and 6 months after irradiation, and x-ray pictures of the fractures were taken 10, 15, 30, 45, 60, 75, and 90 days later. The animals were then killed, and the broken bones were studied histologically. While the fractures of the controls healed completely within 60--75 days, the bones of the irradiated rabbits showed fissures, false articulations, and failing restoration of the medullary canal after 90 to 120 days. Normal healing had been achieved previously in cases where the bone and the nerve were cut through simultaneously. An injection of 10-- 12 ml of an alcoholnovocaine solution (10% alcohol, 0.25% novocaine) into the soft tissue of the distal third of the femur blocked the afferent nerve fibers and thus stimulated the formation of callus considerably without causing morphological changes of the axons. The bones treated this way healed within 60-- 75 days. This result was obtained regardless of whether the solution was injected into the injured leg or into the contralateral extremity, and is attributed to a reflex mechanism in the latter case. The experiments indicated various ways of counteracting the harmful effect of irradiation on the regeneration of bones. (OTS)

• Research Organization: Originating Research Org. not identified
• NSA Number: NSA-17-035609
• OSTI ID: 4656598
• Journal Information: Med. Zh. Uzbekistana, Journal Name: Med. Zh. Uzbekistana Vol. Vol: No. 1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ALCOHOLS
ANESTHESIA
BIOLOGY AND MEDICINE
BONES
DRUGS
NERVOUS SYSTEM
PROCAINE
RABBITS
RADIATION EFFECTS
RADIOGRAPHY
RECOVERY
REGENERATION
SURGERY
TISSUES