Genetics of the. cap alpha. 1,6-dextran response: expression of the QUPC52 idiotype in different inbred and congenic strains of mice
Journal Article
·
· J. Immunol.; (United States)
OSTI ID:5707125
- Litton Bionetics, Kensington, MD
Antibodies to dextran B512 were raised in various strains of mice and were assayed by a radioimunoassay procedure. Idiotypic antibodies to the IgA(k) dextran B512 binding myeloma proteins QUOC52 and W3129 of BALB/c origin were prepred in rabbits. After adsorption, each antiserum was specific for the immunizing myeloma protein and did not react with hundreds of other myeloma proteins; nonetheless, antibodies to dextran B512 from various strains of mice cross-reacted in these test systems. Of the 2 idiotypes tested, the W3129 idiotype was more universally expressed in different strains of mice. The QUPC52 idiotype was the predominant idiotype in BALB/c anti-dextran B512 antibodies and was found in only a few other inbred strains. Using a battery of congenic and inbred strains, it was shown that the QUPC52 idiotype was controlled by genes linked to the Igh complex locus (chromosome 12) and to the Ig k complex locus (chromosome 6). The W3129 idiotype was found in a number of stocks of mice in the genus Mus recently isolated from the wild. The QUPC52 idiotype thus far was found only in inbred mice.
- OSTI ID:
- 5707125
- Journal Information:
- J. Immunol.; (United States), Journal Name: J. Immunol.; (United States) Vol. 128:1; ISSN JOIMA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550400 -- Genetics
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BLOOD SUBSTITUTES
CARBOHYDRATES
CONTROL
DAYS LIVING RADIOISOTOPES
DEXTRAN
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GENES
GENETIC CONTROL
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PEST CONTROL
POLYSACCHARIDES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RODENTS
SACCHARIDES
SPECIFICITY
TRACER TECHNIQUES
VERTEBRATES
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BLOOD SUBSTITUTES
CARBOHYDRATES
CONTROL
DAYS LIVING RADIOISOTOPES
DEXTRAN
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GENES
GENETIC CONTROL
HEMATOLOGIC AGENTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PEST CONTROL
POLYSACCHARIDES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RODENTS
SACCHARIDES
SPECIFICITY
TRACER TECHNIQUES
VERTEBRATES