Paper spot test: a rapid method for quantitating stannous concentrations in radiopharmaceutical kits

Journal Article · Fri May 01 04:00:00 EDT 1981 · J. Nucl. Med.; (United States)

OSTI ID:5706597

Zimmer, A M; Spies, S M

We have developed a simplified, semiquantitative test for the determination of stannous tin in pyrophosphate and other tin-containing radiopharmaceuticals, excluding those stabilized with ascorbic acid and MAA preparations. The test involves the formation and disappearance of a positive red color complex in the presence of Sn(II) and in acidified porphyrin solution. With this technique, the time of spot disappearance is directly proportional to the Sn(II) concentration spotted. The procedure is easy to use, requiring only a high-intensity light source (30-watt light bulb) and a timing device. The test is accurate, reproducible, and sensitive to Sn(II) levels as low as 40 micrograms/ml. Because the procedure is rapid (requiring less than 5 min), it can easily be incorporated into the routine radiopharmaceutical quality-control program of any nuclear medicine facility.

• OSTI ID: 5706597
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
CHEMICAL ANALYSIS
CHEMICAL PREPARATION
CONTROL
DRUGS
ELEMENTS
ESTERS
IMPURITIES
LABELLED COMPOUNDS
MEASURING METHODS
MEDICINE
METALS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
PHOSPHONIC ACID ESTERS
QUALITY CONTROL
QUANTITATIVE CHEMICAL ANALYSIS
RADIOPHARMACEUTICALS
SYNTHESIS
TIME DEPENDENCE
TIN