The effects of dietary carbohydrates on the retention of added lead and uptake of Pb/sup 210/ in tissues of weanling rats

Thesis/Dissertation · Thu Jan 01 04:00:00 EST 1981

OSTI ID:5706162

Nzelibe, C G

Two experiments were conducted in this study. Fifty weanling rats of Holtzman strain were assigned to five treatment groups and fed corn starch (control) diet and/or lactose or sucrose with basal ingredients in various proportions. All the diets had 2000ppm Pb (as lead nitrate) and low - Ca (as calcium carbonate). At the end of eight weeks feeding period, the rats (2 per group) were killed sequentially at intervals of 2, 4, 8, 12, and 24 hours following intramuscular injection of Pb/sup 210/ at 20 ..mu..Ci/100 g body weight. Activity of Pb/sup 210/ in liver of rats fed 30% sucrose and lactose diets was statistically significant P < 0.05 at both 4 and 8 hours. Both diet and time of injection had statistically significant (P < 0.001) effect on Pb/sup 210/ uptake by the serum. There were positive correlations between different variables at different intervals of time. The second part of this study involved atomic absorption spectrophometric analysis of lead content of blood serum, liver, kidneys, brain, heart, urine, and feces. The results showed that lactose in the diet caused increased retention in the tissues except in the brain and kidneys, while sucrose diet lowered the lead content of these tissues. Rats fed 30% sucrose diet showed the highest weight gain and those on 50% lactose diet showed lowest weight gain. The results of this study show that dietary carbohydrate treatment is the main effect on the activity of Pb/sup 210/ in blood serum, liver, kidneys, brain, heart, urine and feces; and a 50% sucrose diet inhibits lead content in these tissues. It also induces removal of lead by the urine, thus reducing the lead burden in the body.

• OSTI ID: 5706162
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METAL COMPOUNDS
ALPHA DECAY RADIOISOTOPES
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOASSAY
BIOLOGICAL ACCUMULATION
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY
BODY FLUIDS
BRAIN
CALCIUM CARBONATES
CALCIUM COMPOUNDS
CARBOHYDRATES
CARBON COMPOUNDS
CARBONATES
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DIET
DIGESTIVE SYSTEM
DISACCHARIDES
ELEMENTS
EVEN-EVEN NUCLEI
FECES
GLANDS
HEART
HEAVY NUCLEI
ISOTOPES
KIDNEYS
LACTOSE
LEAD
LEAD 210
LEAD COMPOUNDS
LEAD ISOTOPES
LEAD NITRATES
LIVER
MAMMALS
MATERIALS
METALS
NERVOUS SYSTEM
NITRATES
NITROGEN COMPOUNDS
NUCLEI
OLIGOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
SACCHAROSE
TISSUES
URINE
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES