RAdiopharmaceutical dosimetry of manganese (Mn-52m) chloride

Conference · Mon Jun 01 04:00:00 EDT 1981 · HHS Publ. (FDA) (U.S.); (United States)

OSTI ID:5706007

Quaife, M A; Dirksen, J W; Quaife, R A; Peters, P L; McIntire, Jr, R H

The application of manganese radiopharmaceuticals in clinical nuclear medicine is predicated upon the essential role of divalent cations in mammalian metabolism. The potential use of Mn-52m in the elucidation of myocardial pathophysiology is presented in a staged experimental design. To provide a biochemical basis, the initial portion of the study evaluated quantitative elemental levels of Mn in a mammalian (rabbit) infarct model. A significant decrease in tissue manganese was shown in infarcted and ischemic tissue. Subsequently the distribution and localization of radioactive manganese were explored in a similar model and confirmed the reduction in Mn level in ischemic and infarcted myocardium. Additionally, temporal changes were assessed after infarction and suggested the elemental level, as mirrored by tracer concentration, provided not only an index of myocardial injury but also a measure of recovery on a biochemical level. The introduction of a new radiopharmaceutical such as Mn-52m, based upon the key role of the divalent cation Mn in myocardial intermediary metabolism, must also be accompanied by delineation of the parameters necessary for dosimetric considerations.

• Research Organization: Univ. of Nebraska Medical Center, Omaha
• OSTI ID: 5706007
• Report Number(s): CONF-801082-
• Conference Information: Journal Name: HHS Publ. (FDA) (U.S.); (United States) Journal Volume: 81-8166
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL LOCALIZATION
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHLORIDES
CHLORINE COMPOUNDS
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DOSES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HALIDES
HALOGEN COMPOUNDS
HEART
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC NUCLEI
ISOTOPES
KINETICS
LABELLED COMPOUNDS
MANGANESE 52
MANGANESE CHLORIDES
MANGANESE COMPOUNDS
MANGANESE HALIDES
MANGANESE ISOTOPES
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGY
PHYSIOLOGY
RADIATION DOSES
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
REACTION KINETICS
TOMOGRAPHY
TRANSITION ELEMENT COMPOUNDS
USES
VASCULAR DISEASES