Manganese-52m, a new short-lived, generator-produced radionuclide: a potential tracer for positron tomography

Conference · Sun Jun 01 04:00:00 EDT 1980 · J. Nucl. Med.; (United States)

OSTI ID:5210261

Atcher, R W; FriedMan, A M; Huizenga, J R; Rayudu, G V.S.; Silverstein, E A; Turner, D A

A new generator system was developed using the Fe-52 ..-->.. Mn-52m parent-daughter pair. Fe-52, half-life 8.3 hr, is isolated on an anion-exchange column, and Mn-52m is eluted in hydrochloric acid. Breakthrough is less than 0.01% and the yield is 75%. The 21.1-min half life of Mn-52m is ideal for use in sequential studies, but is long enough to permit radiochemical manipulations to control biodistribution. Animal studies indicate that Mn-52m is an ideal nuclide for myocardial imaging, combining rapid blood clearance and high concentration in the myocardium. An added advantage is that Mn-52m decays 98% by positron emission and is useful for positron computer tomography.

• Research Organization: Argonne National Lab., IL
• OSTI ID: 5210261
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 21:6
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD-PLASMA CLEARANCE
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
CHROMATOGRAPHY
CLEARANCE
COMPUTERIZED TOMOGRAPHY
DATA
DATA FORMS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GLANDS
GRAPHS
HALF-LIFE
HALIDES
HALOGEN COMPOUNDS
HEART
HOURS LIVING RADIOISOTOPES
INFORMATION
INTERMEDIATE MASS NUCLEI
ION EXCHANGE CHROMATOGRAPHY
IRON 52
IRON 59
IRON ISOTOPES
ISOMERIC NUCLEI
ISOTOPES
KIDNEYS
LIVER
LUNGS
MAMMALS
MANGANESE 52
MANGANESE CHLORIDES
MANGANESE COMPOUNDS
MANGANESE HALIDES
MANGANESE ISOTOPES
MATERIALS
MICE
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RADIOCHEMISTRY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
RODENTS
SEPARATION PROCESSES
SYNTHESIS
TABLES
TISSUE DISTRIBUTION
TOMOGRAPHY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES