Myocardial positron tomography with manganese-52m

Journal Article · Sat Dec 01 04:00:00 EST 1979 · Radiology; (United States)

OSTI ID:5179895

Atkins, H L ^[1]; Som, P; Fairchild, R G; Hui, J; Schachner, E; Goldman, A; Ku, T

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1. Brookhaven National Lab., Upton, NY

The biodistribution of radiomanganese (/sup 54/Mn) was studied in mice, rats, and dogs. Disappearance of radioactivity from the blood was extremely rapid, with a half-time of approximately 0.8 minutes. This resulted in very favorable myocardium-to-blood ratios, even at early times after administration. The myocardial uptake in dogs was greater than 3% at three and 15 minutes, with myocardium-to-blood ratios of about 40:1 at 15 minutes. Positron tomograms obtained with /sup 52m/Mn clearly demonstrated regional myocardial perfusion. There was good correlation (r = 0.89) of microsphere-to-radiomanganese distribution in the infarcted dog heart.

• OSTI ID: 5179895
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 133:3; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD-PLASMA CLEARANCE
BODY
CARDIOVASCULAR SYSTEM
CLEARANCE
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOTOPES
MAMMALS
MANGANESE 52
MANGANESE ISOTOPES
MICE
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-ODD NUCLEI
ORGANS
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
TISSUE DISTRIBUTION
TOMOGRAPHY
VERTEBRATES