Quantitative scanning of osteogenic sarcoma with nitrogen-13-labeled L-glutamate

Journal Article · Sun Jul 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:5704293

Gelbard, A S; Benua, R S; Laughlin, J S; Rosen, G; Reiman, R E; McDonald, J M

The compound /sup 13/N L-glutamate was used to image an osteogenic sarcoma in a 9-year-old patient. Serial quantitative measurements of the amount of /sup 13/N taken up by the primary tumor showed a decrease of 40% after 10 wk of chemotherapy. Blood-clearance data obtained from normal subjects indicate that more than 90% of the /sup 13/N activity had left the blood before scanning of the tumor was begun. It appears that the /sup 13/N label concentrated in the soft-tissue portion of this osteogenic sarcoma, whereas /sup 99m/Tc diphosphonate uptake was greatest in the regions where calcification was occurring.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 5704293
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:7; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH METALS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD-PLASMA CLEARANCE
CALCIUM
CARBOXYLIC ACIDS
CHEMOTHERAPY
CHILDREN
CLEARANCE
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
GLUTAMIC ACID
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
METALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NITROGEN 13
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
OSTEOSARCOMAS
PATIENTS
PHOSPHONATES
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
SARCOMAS
SCINTISCANNING
SKELETAL DISEASES
THERAPY
VERTEBRATES