Imaging of primary Ewing sarcoma with /sup 13/N-L-glutamate
Eleven patients with untreated primary Ewing sarcoma were studied with intravenously administered /sup 13/N-labeled L-glutamate. Seven were repeatedly scanned during chemotherapy using this agent and /sup 99/mTc-methylene diphosphonate (/sup 99/mTc-MDP). The untreated primary tumor was distinctly visualized with /sup 13/N-L-glutamate in all cases; the distribution of /sup 13/N label in the tumor sometimes differed from that of /sup 99/mTc. A kinetic study showed rapid uptake of /sup 13/N by tumor tissue. Repeat scans following therapy indicated that /sup 13/N-L-glutamate and /sup 99/mTc-MDP uptake showed changes consistent with histological findings following subsequent surgery. /sup 13/N uptake often decreased more markedly than /sup 99/mTc uptake during chemotherapy, but metastatic lesions were not visualized with /sup 13/N-L-glutamate. Tumor imaging with this labeled amino acid may be of value in assessing the response of primary Ewing sarcoma to chemotherapy.
- Research Organization:
- Biophysics Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY
- OSTI ID:
- 5405701
- Journal Information:
- Radiology; (United States), Journal Name: Radiology; (United States) Vol. 142:2; ISSN RADLA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
GLUTAMIC ACID
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NITROGEN 13
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PATIENTS
PHOSPHONIC ACID ESTERS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SARCOMAS
SCINTISCANNING
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
TUMOR CELLS
UPTAKE
USES
YEARS LIVING RADIOISOTOPES