Quantitative scanning of soft-tissue sarcomas with nitrogen-13-labeled L-glutamate

Journal Article · Sat Jan 01 04:00:00 EST 1983 · Cancer Invest.; (United States)

DOI:https://doi.org/10.3109/07357908309048507· OSTI ID:6833531

Sordillo, P P; Reiman, R E; Benua, R S; Gelbard, A S; Magill, G B; Rosen, G; Laughlin, J S

Nitrogen-13-L-glutamate, a labeled amino acid enzymatically synthesized from cyclotron-produced N-13 ammonia and alpha-ketoglutaric acid, was used as an imaging agent in 14 patients with soft-tissue sarcomas. Concentration of nitrogen-13 label within the sarcoma was seen in 11 of the 14 patients; in some cases, clinically inapparent metastatic tumor lesions could also be detected. In eight patients, the tumor response to chemotherapy was evaluated by serial studies with this agent. In each case, the change in uptake of N-13 label by the sarcoma after therapy paralleled the clinical response to treatment. N-13-labeled L-glutamate may thus be of value as an imaging agent in the management of patients with soft-tissue sarcomas.

• Research Organization: Memorial Sloan-Kettering Cancer Center, Cornell University School of Medicine, New York, NY
• OSTI ID: 6833531
• Journal Information: Cancer Invest.; (United States), Journal Name: Cancer Invest.; (United States) Vol. 1:5; ISSN CINVD
• Country of Publication: United States
• Language: English

Related Subjects

550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CHEMOTHERAPY
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLUTAMIC ACID
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
METASTASES
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NITROGEN 13
NITROGEN ISOTOPES
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
RADIOISOTOPES
RESONANCE
SARCOMAS
THERAPY
TRACER TECHNIQUES
USES