Autoradiography in fetal golden hamsters treated with tritiated diethylnitrosamine
Journal Article
·
· J. Natl. Cancer Inst.; (United States)
OSTI ID:5702783
Tritiated diethylnitrosamine was administered to female Syrian golden hamsters on each of the last 4 days (days 12-15) of pregnancy. The distribution of bound radioactivity was monitored by light microscopic autoradiography of fetal tracheas and livers, the placentas, and the maternal livers. In the trachea, the fetal target organ, bound radioactivity was restricted to the respiratory epithelium, where diethylnitrosamine-induced tracheal tumors arise. Mucous cells and nonciliated stem cells were identified as the principal sites of binding; other cell types within the tracheal epithelium contained only small amounts of bound radioactivity. The level of binding observed in the fetal trachea increased steadily from day 12 to day 15, which correlated well with the levels of differentiation of this tissue during this period. This observation also agrees with the previously reported observation that tumor incidence increases from 40 to 95% in Syrian golden hamsters between days 12 and 15.
- OSTI ID:
- 5702783
- Journal Information:
- J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 66:4; ISSN JNCIA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Investigation of a potential cotumorigenic effect of the dioxides of nitrogen and sulfur, and of diesel-engine exhaust, on the respiratory tract of Syrian golden hamsters
Oxidative metabolites of diethylstilbestrol in the fetal Syrian golden hamster
Effects of irradiation on canine tracheal epithelium: a physiological and morphological correlate
Journal Article
·
Mon May 01 00:00:00 EDT 1989
· Research Report Health Effects Institue; (USA)
·
OSTI ID:7244299
Oxidative metabolites of diethylstilbestrol in the fetal Syrian golden hamster
Journal Article
·
Fri Nov 30 23:00:00 EST 1984
· Teratology; (United States)
·
OSTI ID:5552173
Effects of irradiation on canine tracheal epithelium: a physiological and morphological correlate
Journal Article
·
Wed Dec 31 23:00:00 EST 1986
· Exp. Lung Res.; (United States)
·
OSTI ID:6273103
Related Subjects
550201 -- Biochemistry-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL LOCALIZATION
BODY
DIGESTIVE SYSTEM
DISTRIBUTION
EPITHELIUM
FETAL MEMBRANES
FETUSES
GLANDS
HAMSTERS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MEMBRANES
METABOLISM
MUCOUS MEMBRANES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PLACENTA
PREGNANCY
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TISSUES
TRACHEA
TRITIUM COMPOUNDS
VERTEBRATES
551001 -- Physiological Systems-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AUTORADIOGRAPHY
BIOLOGICAL LOCALIZATION
BODY
DIGESTIVE SYSTEM
DISTRIBUTION
EPITHELIUM
FETAL MEMBRANES
FETUSES
GLANDS
HAMSTERS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MEMBRANES
METABOLISM
MUCOUS MEMBRANES
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PLACENTA
PREGNANCY
RADIONUCLIDE KINETICS
RESPIRATORY SYSTEM
RODENTS
TISSUE DISTRIBUTION
TISSUES
TRACHEA
TRITIUM COMPOUNDS
VERTEBRATES