Oxidative metabolites of diethylstilbestrol in the fetal Syrian golden hamster
Journal Article
·
· Teratology; (United States)
/sup 14/C-Diethylstilbestrol was administered orally, intraperitoneally, and intrafetally to 15-day pregnant hamsters at a dose of 20 mg/kg body weight, and the radioactivity was determined in the fetus, placenta, and maternal liver after 6 hours. Significant amounts of radioactivity were found in these tissues in every case, indicating maternal-fetal and fetal-maternal transfer of diethylstilbestrol. Part of the radioactivity found in the tissues could not be extracted even after excessive washing. This implied the presence of reactive metabolites. In the fetal and placental extracts, eight oxidative metabolites of diethylstilbestrol were identified by mass fragmentography as hydroxy- and methoxy-derivatives of diethylstilbestrol, pseudodiethylstilbestrol, and dienestrol. The presence of oxidative metabolites in the hamster fetus and the covalent binding to tissue macromolecules are possibly associated with the fetotoxic effects of diethylstilbestrol.
- Research Organization:
- Univ. of Wuerzburg, Federal Republic of Germany
- OSTI ID:
- 5552173
- Journal Information:
- Teratology; (United States), Journal Name: Teratology; (United States) Vol. 30:3; ISSN TJADA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BODY
CARBON 14 COMPOUNDS
CHEMICAL BONDS
COVALENCE
DIGESTIVE SYSTEM
DISTRIBUTION
FETAL MEMBRANES
FETUSES
GLANDS
HAMSTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
METABOLITES
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PLACENTA
POLYPHENOLS
PREGNANCY
RODENTS
STILBESTROL
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BODY
CARBON 14 COMPOUNDS
CHEMICAL BONDS
COVALENCE
DIGESTIVE SYSTEM
DISTRIBUTION
FETAL MEMBRANES
FETUSES
GLANDS
HAMSTERS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MEMBRANE TRANSPORT
MEMBRANES
METABOLITES
ORGANIC COMPOUNDS
ORGANS
PHENOLS
PLACENTA
POLYPHENOLS
PREGNANCY
RODENTS
STILBESTROL
TISSUE DISTRIBUTION
TOXICITY
TRACER TECHNIQUES
VERTEBRATES