Skin tumorigenesis in mice by petroleum asphalts and coal-tar pitches of known polynuclear aromatic hydrocarbon content
Journal Article
·
· Toxicol. Appl. Pharmacol.; (United States)
The tumorigenic effect of polynuclear hydrocarbons contained in petroleum asphalts and coal-tar pitches was investigated in mice given topical applications of coal-tars and asphalts. Polynuclear aromatic hydrocarbons contained in the 2 media included coronene, picene, benzo(e)pyrene, chrysene, benz(a)anthracene and phenanthracene. Asphalt (2.5 mg) or coal-tar pitch (1.7 mg) was applied to a 1 square inch zone of the dorsal skin of adult mice twice a wk for periods up to 82 wk. Both coal tar and asphalt induced epidermal hyperplasia. Animals given asphalt frequently developed amyloidosis, particularly in the spleen and kidney. Coal-tar painted animals developed squamous cell carcinomas, benign squamous cell papillomas and keratoacanthomas. Carcinomas were developed by 31 coal-tar treated mice and by 2 asphalt-treated mice. In all, 91% of the animals developed some form of skin tumor. Subcutaneous and internal tumors were observed in all treatment groups, including lung adenomas, malignant lymphomas, and endometrial carcinoma.
- Research Organization:
- Univ. of Nebraska, Coll. of Medicine, Omaha
- OSTI ID:
- 5702681
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 18:1; ISSN TXAPA
- Country of Publication:
- United States
- Language:
- English
Similar Records
v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid
Histogenesis and progression in ultraviolet light-induced tumors in hairless mice
Histogenesis and progression of ultraviolet light-induced tumors in hairless mice
Journal Article
·
Fri Nov 30 23:00:00 EST 1990
· Proceedings of the National Academy of Sciences of the United States of America; (United States)
·
OSTI ID:5074281
Histogenesis and progression in ultraviolet light-induced tumors in hairless mice
Journal Article
·
Mon Nov 30 23:00:00 EST 1981
· JNCI, J. Natl. Cancer Inst.; (United States)
·
OSTI ID:5509542
Histogenesis and progression of ultraviolet light-induced tumors in hairless mice
Journal Article
·
Mon Nov 30 23:00:00 EST 1981
· J. Natl. Cancer Inst.; (United States)
·
OSTI ID:5511433
Related Subjects
01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
02 PETROLEUM
020600 -- Petroleum-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
ASPHALTS
BENZANTHRACENE
BENZOPYRENE
BITUMENS
BODY
CARCINOGENESIS
CARCINOMAS
CELL PROLIFERATION
CHRYSENE
COAL TAR
CONDENSED AROMATICS
DISEASES
EPIDERMIS
EPITHELIUM
FEMALE GENITALS
HYDROCARBONS
KIDNEYS
LUNGS
LYMPHOMAS
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PHENANTHRENE
PITCHES
POLYCYCLIC AROMATIC HYDROCARBONS
RESPIRATORY SYSTEM
RODENTS
SKIN
SPLEEN
TAR
TISSUES
UTERUS
VERTEBRATES
016000 -- Coal
Lignite
& Peat-- Health & Safety
02 PETROLEUM
020600 -- Petroleum-- Health & Safety
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
AROMATICS
ASPHALTS
BENZANTHRACENE
BENZOPYRENE
BITUMENS
BODY
CARCINOGENESIS
CARCINOMAS
CELL PROLIFERATION
CHRYSENE
COAL TAR
CONDENSED AROMATICS
DISEASES
EPIDERMIS
EPITHELIUM
FEMALE GENITALS
HYDROCARBONS
KIDNEYS
LUNGS
LYMPHOMAS
MAMMALS
MICE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANS
OTHER ORGANIC COMPOUNDS
PATHOGENESIS
PHENANTHRENE
PITCHES
POLYCYCLIC AROMATIC HYDROCARBONS
RESPIRATORY SYSTEM
RODENTS
SKIN
SPLEEN
TAR
TISSUES
UTERUS
VERTEBRATES