Histogenesis and progression of ultraviolet light-induced tumors in hairless mice

Journal Article · Tue Dec 01 04:00:00 EST 1981 · J. Natl. Cancer Inst.; (United States)

OSTI ID:5511433

Kligman, L H; Kligman, A M

Tumor histogenesis and progression were studied in UV-irradiated albino (Skh:hairless-1) and lightly pigmented (Skh:hairless-2) hairless mice. A strongly carcinogenic dose of UV light was used, producing 100% tumor incidence by 35 weeks. The light source emitted mainly UV radiation in the range of 280-320 nm and the less energetic UV radiation up to 400 nm. The resulting epidermal changes and neoplasms resembled those seen in the actinically damaged skin of humans. Microscopic lesions included benign hyperplasia, actinic keratoses, and squamous cell carcinoma in situ and with microinvasion. Clinical tumors were epithelial papillomas, fibropapillomas, keratoacanthomas, cystic keratomas, benign pigmented macules, cutaneous hornlike growths, exophytic and endophytic squamous cell carcinomas of several cytologic types, and fibrosarcomas. Even with this high dose of UV radiation, not all of the small tumors progressed to cancer. Many regressed, including some keratoacanthomas, whereas others remained small and benign for the lifetime of the mouse.

• Research Organization: Univ. of Pennsylvania, Philadelphia
• OSTI ID: 5511433
• Journal Information: J. Natl. Cancer Inst.; (United States), Journal Name: J. Natl. Cancer Inst.; (United States) Vol. 67:6; ISSN JNCIA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARCINOGENESIS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EPIDERMIS
EPITHELIUM
MAMMALS
MICE
MORPHOLOGICAL CHANGES
NEOPLASMS
ORGANS
PATHOGENESIS
PATHOLOGICAL CHANGES
RADIATIONS
RODENTS
SKIN
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES